Traffic came to a standstill on Alligator Alley after a multi-vehicle crash.
Emergency vehicles responded to the scene in Collier County on Interstate 75 north, before Mile Marker 61, Monday afternoon, at around 4.
According to Florida Highway Patrol, the crash involved five cars.
Injuries were reported as a result of the crash.
Northbound lanes have opened after initially getting blocked for a short time so Med Flight could access the scene.
Southbound lanes have since reopened.